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Benedetto Grimaldi

Senior Researcher Tenured - Principal Investigator
Molecular Medicine
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About

Dr. Benedetto Grimaldi obtained in 2001 the degree in Biological Science with a summa cum laude from the University of Rome “La Sapienza”.

After obtained a PhD in Genetics and Molecular Biology under the supervision of Dr. Paola Ballario (University of Rome, La Sapienza, Italy), an expert in the study of epigenetics and signal transduction, Dr. Grimaldi transitioned into a postdoctoral fellowship under the mentorship of Prof. Sassone-Corsi (University of California, Irvine, USA), a leader in the field of circadian clock, metabolism and epigenetics.

In 2011 Dr. Grimaldi joined the Drug Discovery and Development (D3) department at the Istituto Italiano di Tecnologia (IIT), where he began pursuing his own line of research focused on the study of “clock-related pathologies”, and on the identification and evaluation of novel molecules with “clock modulator” activity for therapeutic applications.



All Publications
2024
Romaldini A., Spano R., Veronesi M., Grimaldi B., Bandiera T., Sabella S.
Human Multi-Lineage Liver Organoid Model Reveals Impairment of CYP3A4 Expression upon Repeated Exposure to Graphene Oxide
Cells, vol. 13, (no. 18)
Article Journal
2024
Palomba M., Vecchio D., Allavena G., Capaccio V., De Mei C., Scarpelli R., Grimaldi B.
Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy
Journal of Medicinal Chemistry, vol. 67, (no. 1), pp. 349-379
Article Journal
2024
De Luca E., Pedone D., Scarsi A., Marotta R., Catalano F., Debellis D., Cursi L., Grimaldi B., Moglianetti M., Pompa P.P.
Platinum Nanozyme Probes for Cellular Imaging by Electron Microscopy
Small Science
Article Journal
2024
Waters E., Pucci P., Rahman R., Yatsyshyna A.P., Porter H., Hirst M., Gromnicova R., Kraev I., Mongiardini V., Grimaldi B., Golding J., Fillmore H.L., Gyorffy B., Gangadharannambiar P., Velanis C.N., Heath C.J., Crea F.
REST-dependent glioma progression occurs independently of the repression of the long non-coding RNA HAR1A
PLoS ONE, vol. 19, (no. 11)
Article Journal
2024
Kovachka S., Panosetti M., Grimaldi B., Azoulay S., Di Giorgio A., Duca M.
Small molecule approaches to targeting RNA
Nature Reviews Chemistry, vol. 8, (no. 2), pp. 120-135
Review Journal